C5a causes limited, polymorphonuclear cell-independent, mesenteric ischemia/reperfusion-induced injury☆,☆☆
SD Fleming, D Mastellos, G Karpel-Massler… - Clinical …, 2003 - Elsevier
C5 is critical in the development of local mucosal damage and inflammation as well as in the
development of remote organ injury after mesenteric ischemia/reperfusion (IR). To define the
role of C5a in tissue injury, we treated wild-type mice with a cyclic hexapeptide C5a receptor
antagonist (C5aRa) and administered recombinant C5a to C5 deficient (C5−/−) mice
subjected to mesenteric IR. We demonstrate that at 2-h postreperfusion, C5a administered to
C5−/− mice during IR induces limited intestinal mucosal injury but failed to cause remote …
development of remote organ injury after mesenteric ischemia/reperfusion (IR). To define the
role of C5a in tissue injury, we treated wild-type mice with a cyclic hexapeptide C5a receptor
antagonist (C5aRa) and administered recombinant C5a to C5 deficient (C5−/−) mice
subjected to mesenteric IR. We demonstrate that at 2-h postreperfusion, C5a administered to
C5−/− mice during IR induces limited intestinal mucosal injury but failed to cause remote …
