Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia
T Mizushima, K Obata, H Yamanaka, Y Dai, T Fukuoka… - Pain, 2005 - Elsevier
Alterations in the intracellular signal transduction pathway in primary afferents may
contribute to pain hypersensitivity. We demonstrated that very rapid phosphorylation of p38
mitogen-activated protein kinase occurred in dorsal root ganglion (DRG) neurons that were
participating in the transmission of noxious signals. Capsaicin injection induced
phosphorylated-p38 (p-p38) in small-to-medium diameter sensory neurons with a peak at
2min after capsaicin injection. Furthermore, we examined the p-p38 labeling in the DRG …
contribute to pain hypersensitivity. We demonstrated that very rapid phosphorylation of p38
mitogen-activated protein kinase occurred in dorsal root ganglion (DRG) neurons that were
participating in the transmission of noxious signals. Capsaicin injection induced
phosphorylated-p38 (p-p38) in small-to-medium diameter sensory neurons with a peak at
2min after capsaicin injection. Furthermore, we examined the p-p38 labeling in the DRG …