[HTML][HTML] 11, 12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1
M Potente, B Fisslthaler, R Busse, I Fleming - Journal of biological chemistry, 2003 - ASBMB
Cytochrome P450-derived epoxyeicosatrienoic acids (EETs) stimulate endothelial cell
proliferation and angiogenesis. In this study, we investigated the involvement of the forkhead
box, class O (FOXO) family of transcription factors and their downstream target p27 Kip1 in
EET-induced endothelial cell proliferation. Incubation of human umbilical vein endothelial
cells with 11, 12-EET induced a time-and dose-dependent decrease in p27 Kip1 protein
expression, whereas p21 Cip1 was not significantly affected. This effect on p27 Kip1 protein …
proliferation and angiogenesis. In this study, we investigated the involvement of the forkhead
box, class O (FOXO) family of transcription factors and their downstream target p27 Kip1 in
EET-induced endothelial cell proliferation. Incubation of human umbilical vein endothelial
cells with 11, 12-EET induced a time-and dose-dependent decrease in p27 Kip1 protein
expression, whereas p21 Cip1 was not significantly affected. This effect on p27 Kip1 protein …