[HTML][HTML] The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration
RL Meighan-Mantha, DKW Hsu, Y Guo… - Journal of Biological …, 1999 - ASBMB
The binding of polypeptide growth factors to their appropriate cell surface transmembrane
receptors triggers numerous biochemical responses, including the transcriptional activation
of specific genes. We have used a differential display approach to identify fibroblast growth
factor-1-inducible genes in murine NIH 3T3 cells. Here, we report that the fibroblast growth
factor-inducible-14 (Fn14) gene is a growth factor-regulated, immediate-early response
gene expressed in a developmental stage-and adult tissue-specific manner in vivo. This …
receptors triggers numerous biochemical responses, including the transcriptional activation
of specific genes. We have used a differential display approach to identify fibroblast growth
factor-1-inducible genes in murine NIH 3T3 cells. Here, we report that the fibroblast growth
factor-inducible-14 (Fn14) gene is a growth factor-regulated, immediate-early response
gene expressed in a developmental stage-and adult tissue-specific manner in vivo. This …