Publisher Summary This chapter summarizes the experimental findings and observations
based on the nonobese diabetic (NOD) mouse model and discusses the pathogenesis and
the etiology of autoimmune diabetes. To elucidate the etiology of insulin-dependent
diabetes mellitus (IDDM), several animal models have been developed, including
experimentally induced and spontaneously developing models. One is low-dose
streptozocin-induced diabetes. A high dose of streptozocin destroys completely pancreatic β …