Rheumatoid factor revisited
In patients with rheumatoid arthritis, the induction of rheumatoid factors can be taken as an
indicator of severe disease with a striking involvement of B cell activation. Very recent
clinical trials using B cell depletion support the concept that humoral immunity, as evidenced
by the production of rheumatoid factors, plays a significant role in the course of the disease.
indicator of severe disease with a striking involvement of B cell activation. Very recent
clinical trials using B cell depletion support the concept that humoral immunity, as evidenced
by the production of rheumatoid factors, plays a significant role in the course of the disease.
Summary
In patients with rheumatoid arthritis, the induction of rheumatoid factors can be taken as an indicator of severe disease with a striking involvement of B cell activation. Very recent clinical trials using B cell depletion support the concept that humoral immunity, as evidenced by the production of rheumatoid factors, plays a significant role in the course of the disease.
Lippincott Williams & Wilkins