Previous studies have shown that normal human intestinal epithelial cells stimulate CD8+
suppressor T cell proliferation in an allogeneic mixed epithelial/T cell co-culture system,
which is neither restricted by class I or class II major histocompatibility complex antigens nor
by any soluble factors from epithelial cells. Two epithelial specific monoclonal antibodies
(mAb), mAb B9 and mAb L12, are potent inhibitors of this mixed epithelial/T cell reaction but
not of conventional mixed lymphocyte reactions. While phenotypically distinct by tissue …