We have recently found that soluble biglycan purified from rat thymic myoid cells had
haemopoietic activity capable of inducing preferential growth and differentiation of
monocytic lineage cells from various haemopoietic sources, including brain microglial cells.
In the present study, to understand developmental mechanisms of microglial/monocytic cells
in the brain, we have attempted to identify haemopoietic activity of the brain biglycan. The
mRNA and the immunological epitope of biglycan were detected in the rat brain …