[HTML][HTML] FXR-mediated down-regulation of CYP7A1 dominates LXRα in long-term cholesterol-fed NZW rabbits
G Xu, H Li, L Pan, Q Shang, A Honda… - Journal of lipid …, 2003 - ASBMB
We investigated how cholesterol feeding regulates cholesterol 7α-hydroxylase (CYP7A1)
via the nuclear receptors farnesoid X receptor (FXR) and liver X receptor α (LXRα) in New
Zealand white rabbits. After 1 day of 2% cholesterol feeding, when the bile acid pool size
had not expanded, mRNA levels of the FXR target genes short-heterodimer partner (SHP)
and sterol 12α-hydroxylase (CYP8B) were unchanged, indicating that FXR activation
remained constant. In contrast, the mRNA levels of the LXRα target genes ATP binding …
via the nuclear receptors farnesoid X receptor (FXR) and liver X receptor α (LXRα) in New
Zealand white rabbits. After 1 day of 2% cholesterol feeding, when the bile acid pool size
had not expanded, mRNA levels of the FXR target genes short-heterodimer partner (SHP)
and sterol 12α-hydroxylase (CYP8B) were unchanged, indicating that FXR activation
remained constant. In contrast, the mRNA levels of the LXRα target genes ATP binding …