Gallstone formation: local factors
CW Ko, SP Lee - Gastroenterology Clinics of North America, 1999 - Elsevier
In 1882, Langenbuch performed the first cholecystectomy. 7, 58 At the time, he hypothesized
that removing the gallbladder was necessary because it was a culprit in stone formation.
Previously the gallbladder was believed to be a simple storage organ and an innocent
bystander. Subsequent investigations have supported Langenbuch's hypothesis. Once the
gallbladder is removed, formation of recurrent cholesterol gallstones is extremely rare. It is
well documented that secretion of supersaturated bile by the liver is essential for cholesterol …
that removing the gallbladder was necessary because it was a culprit in stone formation.
Previously the gallbladder was believed to be a simple storage organ and an innocent
bystander. Subsequent investigations have supported Langenbuch's hypothesis. Once the
gallbladder is removed, formation of recurrent cholesterol gallstones is extremely rare. It is
well documented that secretion of supersaturated bile by the liver is essential for cholesterol …