Fibrates are widely used hypolipidemic drugs that regulate the expression of many genes
involved in lipid metabolism by activating the peroxisome proliferator-activated receptor α
(PPARα). The objective of this study was to investigate the mechanism of action of
peroxisome proliferators and PPARα on the transcription of cholesterol 7α-hydroxylase, the
rate-limiting enzyme in the conversion of cholesterol to bile acids in the liver. When
cotransfected with the expression vectors for PPARα and RXRα, Wy14, 643 reduced human …