Ascorbic acid: a scavenger of superoxide radical.

S Som, C Raha, IB Chatterjee - Acta vitaminologica et enzymologica, 1983 - europepmc.org
S Som, C Raha, IB Chatterjee
Acta vitaminologica et enzymologica, 1983europepmc.org
The second order rate constant for the reaction between ascorbic acid and superoxide at pH
7.4 using the xanthine-xanthine oxidase system was estimated to be 5.4 x 10 (6) M-1 sec-1.
The results indicate that the efficacies of superoxide dismutase and ascorbic acid for
catalyzing the decay of superoxide radical in animal tissues are similar. The significance of
ascorbic acid as a scavenger of superoxide is discussed from the point of view of evolution
of ascorbic acid synthesizing capacity in the terrestrial vertebrates.
The second order rate constant for the reaction between ascorbic acid and superoxide at pH 7.4 using the xanthine-xanthine oxidase system was estimated to be 5.4 x 10 (6) M-1 sec-1. The results indicate that the efficacies of superoxide dismutase and ascorbic acid for catalyzing the decay of superoxide radical in animal tissues are similar. The significance of ascorbic acid as a scavenger of superoxide is discussed from the point of view of evolution of ascorbic acid synthesizing capacity in the terrestrial vertebrates.
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