Modulation of nitric oxide responses in asthma by extracellular antioxidants
OCTOBER 1999 is in excess of 109 M–1s–1), 20 then any O2–present in the extracellular
spaces would preferentially react with NO, forming ONOO–. The formation of ONOO–may
change the function of NO as a signal transduction agent. ONOO–is a potent nitrating
species and readily nitrates tyrosine residues of proteins. 21 The byproduct of this reaction is
the formation of nitrotyrosine residues and is a commonly used footprint for the presence of
ONOO–. However, not all nitrotyrosine may be formed through the reaction with ONOO …
spaces would preferentially react with NO, forming ONOO–. The formation of ONOO–may
change the function of NO as a signal transduction agent. ONOO–is a potent nitrating
species and readily nitrates tyrosine residues of proteins. 21 The byproduct of this reaction is
the formation of nitrotyrosine residues and is a commonly used footprint for the presence of
ONOO–. However, not all nitrotyrosine may be formed through the reaction with ONOO …