CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?

Z Grossman, M Meier-Schellersheim, AE Sousa… - Nature medicine, 2002 - nature.com
Z Grossman, M Meier-Schellersheim, AE Sousa, RMM Victorino, WE Paul
Nature medicine, 2002nature.com
Is CD4+ cell depletion due to rapid elimination by HIV and failure of the immune system to
replace these cells at the required rate? Increasing evidence suggests that this is not the
case, and that infection-induced immune activation drives both viral replication and CD4+
cell depletion.
Is CD4+ cell depletion due to rapid elimination by HIV and failure of the immune system to replace these cells at the required rate? Increasing evidence suggests that this is not the case, and that infection-induced immune activation drives both viral replication and CD4+ cell depletion.
nature.com