Beneficial effect of pharmacological mobilization of bone marrow in experimental cerebral ischemia
I Six, G Gasan, E Mura, R Bordet - European journal of pharmacology, 2003 - Elsevier
I Six, G Gasan, E Mura, R Bordet
European journal of pharmacology, 2003•ElsevierBone marrow stem cells are able to differentiate into nervous and endothelial cells. In our
study, we found that administration of a bone marrow-stimulating factor (granulocyte colony-
stimulating factor; G-CSF 50 μg/kg) decrease the brain infarct volume and enhance survival
rate in a model of cerebral ischemia. Taken together, these data suggest a beneficial effect
of a pharmacological endogenous bone marrow mobilization in the course of cerebral
ischemia and open a new direction for cellular therapy strategy in stroke.
study, we found that administration of a bone marrow-stimulating factor (granulocyte colony-
stimulating factor; G-CSF 50 μg/kg) decrease the brain infarct volume and enhance survival
rate in a model of cerebral ischemia. Taken together, these data suggest a beneficial effect
of a pharmacological endogenous bone marrow mobilization in the course of cerebral
ischemia and open a new direction for cellular therapy strategy in stroke.
Bone marrow stem cells are able to differentiate into nervous and endothelial cells. In our study, we found that administration of a bone marrow-stimulating factor (granulocyte colony-stimulating factor; G-CSF 50 μg/kg) decrease the brain infarct volume and enhance survival rate in a model of cerebral ischemia. Taken together, these data suggest a beneficial effect of a pharmacological endogenous bone marrow mobilization in the course of cerebral ischemia and open a new direction for cellular therapy strategy in stroke.
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