Transcription-dependent and-independent control of neuronal survival by the PI3K–Akt signaling pathway
Current opinion in neurobiology, 2001•Elsevier
The PI3K–Akt signaling pathway plays a critical role in mediating survival signals in a wide
range of neuronal cell types. The recent identification of a number of substrates for the
serine/threonine kinase Akt suggests that it blocks cell death by both impinging on the
cytoplasmic cell death machinery and by regulating the expression of genes involved in cell
death and survival. In addition, recent experiments suggest that Akt may also use metabolic
pathways to regulate cell survival.
range of neuronal cell types. The recent identification of a number of substrates for the
serine/threonine kinase Akt suggests that it blocks cell death by both impinging on the
cytoplasmic cell death machinery and by regulating the expression of genes involved in cell
death and survival. In addition, recent experiments suggest that Akt may also use metabolic
pathways to regulate cell survival.
The PI3K–Akt signaling pathway plays a critical role in mediating survival signals in a wide range of neuronal cell types. The recent identification of a number of substrates for the serine/threonine kinase Akt suggests that it blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell death and survival. In addition, recent experiments suggest that Akt may also use metabolic pathways to regulate cell survival.
Elsevier