[HTML][HTML] Granulocyte colony-stimulating factor induces ERK5 activation, which is differentially regulated by protein-tyrosine kinases and protein kinase C: regulation of …
F Dong, JS Gutkind, AC Larner - Journal of biological chemistry, 2001 - ASBMB
Granulocyte colony-stimulating factor (G-CSF) plays a major role in the regulation of
granulopoiesis. Treatment of cells with G-CSF has been shown to activate multiple signal
transduction pathways. We show here that Erk5, a novel member of the MAPK family, and its
specific upstream activator MEK5 were activated in response to incubation of cells with G-
CSF. Different from other members of the MAPK family including Erk1/2, JNK, and p38,
maximal activation of Erk5 by G-CSF required the C-terminal region of the G-CSF receptor …
granulopoiesis. Treatment of cells with G-CSF has been shown to activate multiple signal
transduction pathways. We show here that Erk5, a novel member of the MAPK family, and its
specific upstream activator MEK5 were activated in response to incubation of cells with G-
CSF. Different from other members of the MAPK family including Erk1/2, JNK, and p38,
maximal activation of Erk5 by G-CSF required the C-terminal region of the G-CSF receptor …