Protection against hypoxic–ischemic injury in transgenic mice overexpressing Kir6. 2 channel pore in forebrain
L Héron-Milhavet, Y Xue-Jun, SJ Vannucci… - Molecular and Cellular …, 2004 - Elsevier
The role of the K-ATP channel pore-forming subunit Kir6. 2 on protection from cerebral
hypoxic–ischemic injury was assessed in transgenic mice overexpressing normal Kir6. 2 or
a dominant negative form (AFA) of this subunit in the forebrain. The resulting mice
overexpress either the Kir6. 2 or the AFA transgene mainly in the cerebral cortex and
hippocampus. The Kir6. 2 transgenic mice are resistant to hypoxic–ischemic injury showing
a decreased region of cortical damage as compared to the dominant negative AFA and the …
hypoxic–ischemic injury was assessed in transgenic mice overexpressing normal Kir6. 2 or
a dominant negative form (AFA) of this subunit in the forebrain. The resulting mice
overexpress either the Kir6. 2 or the AFA transgene mainly in the cerebral cortex and
hippocampus. The Kir6. 2 transgenic mice are resistant to hypoxic–ischemic injury showing
a decreased region of cortical damage as compared to the dominant negative AFA and the …