[HTML][HTML] Functional and structural analysis of ClC-K chloride channels involved in renal disease
S Waldegger, TJ Jentsch - Journal of Biological Chemistry, 2000 - ASBMB
ClC-K channels belong to the CLC family of chloride channels and are predominantly
expressed in the kidney. Genetic evidence suggests their involvement in transepithelial
transport of chloride in distal nephron segments; ClC-K1 gene deletion leads to nephrogenic
diabetes insipidus in mice, and mutations of the hClC-Kb gene cause Bartter's syndrome
type III in humans. Expression of rClC-K1 in Xenopus oocytes yielded voltage-independent
currents that were pH-sensitive, had a Br−> NO 3−= Cl−> I− conductance sequence, and …
expressed in the kidney. Genetic evidence suggests their involvement in transepithelial
transport of chloride in distal nephron segments; ClC-K1 gene deletion leads to nephrogenic
diabetes insipidus in mice, and mutations of the hClC-Kb gene cause Bartter's syndrome
type III in humans. Expression of rClC-K1 in Xenopus oocytes yielded voltage-independent
currents that were pH-sensitive, had a Br−> NO 3−= Cl−> I− conductance sequence, and …