[HTML][HTML] Familial Hemiplegic Migraine Mutations Change α1ACa2+ Channel Kinetics
RL Kraus, MJ Sinnegger, H Glossmann… - Journal of Biological …, 1998 - ASBMB
Missense mutations in the pore-forming human α 1A subunit of neuronal P/Q-type Ca 2+
channels are associated with familial hemiplegic migraine (FHM). The pathophysiological
consequences of these mutations are unknown. We have introduced the four single
mutations reported for the human α 1A subunit into the conserved rabbit α 1A (R192Q,
T666M, V714A, and I1819L) and investigated possible changes in channel function after
functional expression of mutant subunits in Xenopus laevis oocytes. Changes in channel …
channels are associated with familial hemiplegic migraine (FHM). The pathophysiological
consequences of these mutations are unknown. We have introduced the four single
mutations reported for the human α 1A subunit into the conserved rabbit α 1A (R192Q,
T666M, V714A, and I1819L) and investigated possible changes in channel function after
functional expression of mutant subunits in Xenopus laevis oocytes. Changes in channel …