[CITATION][C] Paramyotonia and MH

GC Allen - Canadian journal of anaesthesia, 1993 - Springer
GC Allen
Canadian journal of anaesthesia, 1993Springer
2 Fobe F, Kestens-Servaye Y, Baele PH, Goenen M. Hearttransplant and mono-amine
oxidase inhibitors. Acta Anaesthesiol Belg 1989; 40: 131-8. ence of anaesthetic triggers. In
myotonic dystrophy, there is an abnormal influx of extracellular calcium, leading to muscle
damage. In a report by Aldridge of 49 anaesthetics given to 17 myotonic dystrophy patients,
there were no cases of MH, despite the frequent use of volatile agents. 7 This is the largest
series reported in such patients, as far as I am aware. Newberg et al. were unable to trigger …
2 Fobe F, Kestens-Servaye Y, Baele PH, Goenen M. Hearttransplant and mono-amine oxidase inhibitors. Acta Anaesthesiol Belg 1989; 40: 131-8. ence of anaesthetic triggers. In myotonic dystrophy, there is an abnormal influx of extracellular calcium, leading to muscle damage. In a report by Aldridge of 49 anaesthetics given to 17 myotonic dystrophy patients, there were no cases of MH, despite the frequent use of volatile agents. 7 This is the largest series reported in such patients, as far as I am aware. Newberg et al. were unable to trigger MH episodes in myotonic goats, the classic animal model of myotonia congenita. 8 Hopefully, as we gain more knowledge about the pathophysiology of muscle disorders, a number of misconceptions regarding the association of MH to other myopathies can be put to rest.
Springer