[HTML][HTML] Long QT syndrome: from channels to cardiac arrhythmias

AJ Moss, RS Kass - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
AJ Moss, RS Kass
The Journal of clinical investigation, 2005Am Soc Clin Investig
Long QT syndrome, a rare genetic disorder associated with life-threatening arrhythmias, has
provided a wealth of information about fundamental mechanisms underlying human cardiac
electrophysiology that has come about because of truly collaborative interactions between
clinical and basic scientists. Our understanding of the mechanisms that control the critical
plateau and repolarization phases of the human ventricular action potential has been raised
to new levels through these studies, which have clarified the manner in which both …
Long QT syndrome, a rare genetic disorder associated with life-threatening arrhythmias, has provided a wealth of information about fundamental mechanisms underlying human cardiac electrophysiology that has come about because of truly collaborative interactions between clinical and basic scientists. Our understanding of the mechanisms that control the critical plateau and repolarization phases of the human ventricular action potential has been raised to new levels through these studies, which have clarified the manner in which both potassium and sodium channels regulate this critical period of electrical activity.
The Journal of Clinical Investigation