Control of MHC Restriction by TCR Vα CDR1 and CDR2
BC Sim, L Zerva, MI Greene, NRJ Gascoigne - Science, 1996 - science.org
BC Sim, L Zerva, MI Greene, NRJ Gascoigne
Science, 1996•science.orgIndividual T cell receptor (TCR) Vα elements are expressed preferentially in CD4 or CD8
peripheral T cell subsets. The closely related Vα3. 1 and Vα3. 2 elements show reciprocal
selection into CD4 and CD8 subsets, respectively. Transgenic mice expressing site-directed
mutants of a Vα3. 1 gene were used to show that individual residues in either the
complementarity-determining region 1 (CDR1) or CDR2 were sufficient to change selection
from the CD4 subset to the CD8 subset. Thus, the germline-encoded Vα elements are a …
peripheral T cell subsets. The closely related Vα3. 1 and Vα3. 2 elements show reciprocal
selection into CD4 and CD8 subsets, respectively. Transgenic mice expressing site-directed
mutants of a Vα3. 1 gene were used to show that individual residues in either the
complementarity-determining region 1 (CDR1) or CDR2 were sufficient to change selection
from the CD4 subset to the CD8 subset. Thus, the germline-encoded Vα elements are a …
Individual T cell receptor (TCR) Vα elements are expressed preferentially in CD4 or CD8 peripheral T cell subsets. The closely related Vα3.1 and Vα3.2 elements show reciprocal selection into CD4 and CD8 subsets, respectively. Transgenic mice expressing site-directed mutants of a Vα3.1 gene were used to show that individual residues in either the complementarity-determining region 1 (CDR1) or CDR2 were sufficient to change selection from the CD4 subset to the CD8 subset. Thus, the germline-encoded Vα elements are a major influence on major histocompatibility class complex (MHC) restriction, most likely by a preferential interaction with one or the other class of MHC molecule.
AAAS