Fibroblast growth factors as multifunctional signaling factors
G Szebenyi, JF Fallon - International review of cytology, 1998 - Elsevier
The fibroblast growth factor (FGF) family consists of at least 15 structurally related
polypeptide growth factors. Their expression is controlled at the levels of transcription,
mRNA stability, and translation. The bioavailability of FGFs is further modulated by
posttranslational processing and regulated protein trafficking. FGFs bind to receptor tyrosine
kinases (FGFRs), heparan sulfate proteoglycans (HSPG), and a cysteine-rich FGF receptor
(CFR). FGFRs are required for most biological activities of FGFs. HSPGs alter FGF-FGFR …
polypeptide growth factors. Their expression is controlled at the levels of transcription,
mRNA stability, and translation. The bioavailability of FGFs is further modulated by
posttranslational processing and regulated protein trafficking. FGFs bind to receptor tyrosine
kinases (FGFRs), heparan sulfate proteoglycans (HSPG), and a cysteine-rich FGF receptor
(CFR). FGFRs are required for most biological activities of FGFs. HSPGs alter FGF-FGFR …