Hydroxylation of HIF-1: oxygen sensing at the molecular level
GL Semenza - Physiology, 2004 - journals.physiology.org
GL Semenza
Physiology, 2004•journals.physiology.orgThe ability to sense and respond to changes in oxygenation represents a fundamental
property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the
identification of protein hydroxylation as a mechanism by which changes in Po2 are
transduced to effect changes in gene expression.
property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the
identification of protein hydroxylation as a mechanism by which changes in Po2 are
transduced to effect changes in gene expression.
The ability to sense and respond to changes in oxygenation represents a fundamental property of all metazoan cells. The discovery of the transcription factor HIF-1 has led to the identification of protein hydroxylation as a mechanism by which changes in Po2 are transduced to effect changes in gene expression.
American Physiological Society