Inhibition of Influenza Virus Replication in Tissue Culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): Mechanism of Action
P Palese, RW Compans - Journal of General Virology, 1976 - microbiologyresearch.org
P Palese, RW Compans
Journal of General Virology, 1976•microbiologyresearch.orgSUMMARY The neuraminidase inhibitor 2-deoxy-2, 3-dehydro-N-trifluoroacetylneuraminic
acid (FANA) inhibits the multicycle replication of influenza viruses in tissue culture. Influenza
virus grown in the presence of FANA contains neuraminic acid on its envelope which then
serves as receptor for other virus particles causing extensive aggregation. Thus, FANA
inhibits influenza virus replication by preventing the enzymatic removal of neuraminic acid
from the virus envelope.
acid (FANA) inhibits the multicycle replication of influenza viruses in tissue culture. Influenza
virus grown in the presence of FANA contains neuraminic acid on its envelope which then
serves as receptor for other virus particles causing extensive aggregation. Thus, FANA
inhibits influenza virus replication by preventing the enzymatic removal of neuraminic acid
from the virus envelope.
Summary
The neuraminidase inhibitor 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA) inhibits the multicycle replication of influenza viruses in tissue culture. Influenza virus grown in the presence of FANA contains neuraminic acid on its envelope which then serves as receptor for other virus particles causing extensive aggregation. Thus, FANA inhibits influenza virus replication by preventing the enzymatic removal of neuraminic acid from the virus envelope.
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