Human cortical distal nephron: distribution of electrolyte and water transport pathways

HL Biner, MP Arpin-Bott, J Loffing, X Wang… - Journal of the …, 2002 - journals.lww.com
The exact distributions of the different salt transport systems along the human cortical distal
nephron are unknown. Immunohistochemistry was performed on serial cryostat sections of
healthy parts of tumor nephrectomized human kidneys to study the distributions in the distal
convolution of the thiazide-sensitive Na-Cl cotransporter (NCC), the β subunit of the
amiloride-sensitive epithelial Na channel (ENaC), the vasopressin-sensitive water channel
aquaporin 2 (AQP2), and aquaporin 3 (AQP3), the H+ ATPase, the Na-Ca exchanger (NCX) …