B-cell tolerance
CC Goodnow - Current opinion in immunology, 1992 - Elsevier
Current opinion in immunology, 1992•Elsevier
Discrimination between self and non-self in humoral immunity is mediated in part by
elimination or inactivation of self-reactive B-cell clones. This type of repertoire censoring
requires that self-reactive B cells make a choice between these and alternative cellular fates.
The details of this developmental decision-making and the steps where it is prone to go awry
in autoimmunity have yet to be untangled, but genetic analysis appears likely to lead the
way.
elimination or inactivation of self-reactive B-cell clones. This type of repertoire censoring
requires that self-reactive B cells make a choice between these and alternative cellular fates.
The details of this developmental decision-making and the steps where it is prone to go awry
in autoimmunity have yet to be untangled, but genetic analysis appears likely to lead the
way.
Abstract
Discrimination between self and non-self in humoral immunity is mediated in part by elimination or inactivation of self-reactive B-cell clones. This type of repertoire censoring requires that self-reactive B cells make a choice between these and alternative cellular fates. The details of this developmental decision-making and the steps where it is prone to go awry in autoimmunity have yet to be untangled, but genetic analysis appears likely to lead the way.
Elsevier