FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4
MH Xie, I Holcomb, B Deuel, P Dowd, A Huang… - Cytokine, 1999 - Elsevier
MH Xie, I Holcomb, B Deuel, P Dowd, A Huang, A Vagts, J Foster, J Liang, J Brush, Q Gu…
Cytokine, 1999•ElsevierWe have identified a novel fibroblast growth factor, FGF-19, the most distant member of the
FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4
and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-
19 maps to chromosome 11 q13. 1, a region associated with an osteoporosis-pseudoglioma
syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues
including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed …
FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4
and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-
19 maps to chromosome 11 q13. 1, a region associated with an osteoporosis-pseudoglioma
syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues
including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed …
We have identified a novel fibroblast growth factor, FGF-19, the most distant member of the FGF family described to date. FGF-19 is a high affinity, heparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13.1, a region associated with an osteoporosis-pseudoglioma syndrome of skeletal and retinal defects. FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line.
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