Anti ICAM-1 (CD 54) monoclonal antibody reduces inflammatory changes in experimental bacterial meningitis

JR Weber, K Angstwurm, W Bürger… - Journal of …, 1995 - Elsevier
We investigated whether monoclonal antibodies directed against intracellular adhesion
molecule 1 (ICAM-1 mAb) inhibit brain edema, increase of intracranial pressure (ICP),
regional cerebral blood flow (rCBF) and recruitment of white blood cells (WBC) into the
cerebrospinal fluid (CSF) in the rat model of the early phase of bacterial meningitis. Brain
edema was assessed by brain water content determinations. rCBF measured by laser
Doppler flowmetry and ICP were recorded continuously for 6 h after intracisternal challenge …