Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-κB
DE Joyce, BW Grinnell - Critical care medicine, 2002 - journals.lww.com
Objective To review the anti-inflammatory and anti-apoptotic properties of drotrecogin alfa
(activated)(recombinant human activated protein C), emphasizing its modulatory effects on
endothelial nuclear factor-κB. We propose a broad anti-inflammatory effect of drotrecogin
alfa (activated), acting on both endothelium and monocytes.
(activated)(recombinant human activated protein C), emphasizing its modulatory effects on
endothelial nuclear factor-κB. We propose a broad anti-inflammatory effect of drotrecogin
alfa (activated), acting on both endothelium and monocytes.