Complete genomic screen in late-onset familial Alzheimer disease: evidence for a new locus on chromosome 12
MA Pericak-Vance, MP Bass, LH Yamaoka, PC Gaskell… - Jama, 1997 - jamanetwork.com
Context.—Four genetic loci have been identified as contributing to Alzheimer disease (AD),
including the amyloid precursor protein gene, the presenilin 1 gene, the presenilin 2 gene,
and the apolipoprotein E gene, but do not account for all the genetic risk for AD. Objective.—
To identify additional genetic risk factors for late-onset AD. Design.—A complete genomic
screen was performed (N= 280 markers). Critical values for chromosomal regional follow-up
were aPvalue of. 05 or less for affected relative pair analysis or sibpair analysis, a …
including the amyloid precursor protein gene, the presenilin 1 gene, the presenilin 2 gene,
and the apolipoprotein E gene, but do not account for all the genetic risk for AD. Objective.—
To identify additional genetic risk factors for late-onset AD. Design.—A complete genomic
screen was performed (N= 280 markers). Critical values for chromosomal regional follow-up
were aPvalue of. 05 or less for affected relative pair analysis or sibpair analysis, a …