Human dysbindin (dtnbp1) gene expression innormal brain and in schizophrenic prefrontal cortex and midbrain
CS Weickert, RE Straub, BW McClintock… - Archives of general …, 2004 - jamanetwork.com
Context The schizophrenia-susceptibility gene dysbindin (DTNBP1on 6p22. 3) encodes a
neuronal protein that binds to β-dystrobrevin and may be part of the dystrophin protein
complex. Little is known about dysbindin expression in normal or schizophrenic brain.
Objectives To determine whether brain regions implicated in schizophrenia express
dysbindin and whether abnormal levels of dysbindin messenger RNA (mRNA) may be found
in this disorder and to test whether sequence variations in the dysbindin gene in the …
neuronal protein that binds to β-dystrobrevin and may be part of the dystrophin protein
complex. Little is known about dysbindin expression in normal or schizophrenic brain.
Objectives To determine whether brain regions implicated in schizophrenia express
dysbindin and whether abnormal levels of dysbindin messenger RNA (mRNA) may be found
in this disorder and to test whether sequence variations in the dysbindin gene in the …