Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22
LM Brzustowicz, KA Hodgkinson, EWC Chow… - Science, 2000 - science.org
LM Brzustowicz, KA Hodgkinson, EWC Chow, WG Honer, AS Bassett
Science, 2000•science.orgSchizophrenia is a complex disorder, and there is substantial evidence supporting a genetic
etiology. Despite this, prior attempts to localize susceptibility loci have produced
predominantly suggestive findings. A genome-wide scan for schizophrenia susceptibility loci
in 22 extended families with high rates of schizophrenia provided highly significant evidence
of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the
likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to …
etiology. Despite this, prior attempts to localize susceptibility loci have produced
predominantly suggestive findings. A genome-wide scan for schizophrenia susceptibility loci
in 22 extended families with high rates of schizophrenia provided highly significant evidence
of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the
likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to …
Schizophrenia is a complex disorder, and there is substantial evidence supporting a genetic etiology. Despite this, prior attempts to localize susceptibility loci have produced predominantly suggestive findings. A genome-wide scan for schizophrenia susceptibility loci in 22 extended families with high rates of schizophrenia provided highly significant evidence of linkage to chromosome 1 (1q21-q22), with a maximum heterogeneity logarithm of the likelihood of linkage (lod) score of 6.50. This linkage result should provide sufficient power to allow the positional cloning of the underlying susceptibility gene.
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