Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
EH Corder, AM Saunders, WJ Strittmatter… - Science, 1993 - science.org
EH Corder, AM Saunders, WJ Strittmatter, DE Schmechel, PC Gaskell, GW Small, AD Roses…
Science, 1993•science.orgThe apolipoprotein E type 4 allele (APOE-ε4) is genetically associated with the common late
onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from
20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number
of APOE-ε4 alleles in 42 families with late onset AD. Thus APOE-ε4 gene dose is a major
risk factor for late onset AD and, in these families, homozygosity for APOE-ε4 was virtually
sufficient to cause AD by age 80.
onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from
20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number
of APOE-ε4 alleles in 42 families with late onset AD. Thus APOE-ε4 gene dose is a major
risk factor for late onset AD and, in these families, homozygosity for APOE-ε4 was virtually
sufficient to cause AD by age 80.
The apolipoprotein E type 4 allele (APOE-ε4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-ε4 alleles in 42 families with late onset AD. Thus APOE-ε4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-ε4 was virtually sufficient to cause AD by age 80.
AAAS