WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain
M O'Reilly, E Marshall, HJL Speirs… - Journal of the American …, 2003 - journals.lww.com
WNK1 is a member of a novel serine/threonine kinase family, With-No-K,(lysine). Intronic
deletions in the encoding gene cause Gordon syndrome, an autosomal dominant,
hypertensive, hyperkalemic disorder particularly responsive to thiazide diuretics, a first-line
treatment in essential hypertension. To elucidate the novel WNK1 BP control pathway active
in distal nephron, WNK1 expression in mouse was studied. It was found that WNK1 is highly
expressed in testis> heart, lung, kidney, placenta> skeletal muscle, brain, and widely at low …
deletions in the encoding gene cause Gordon syndrome, an autosomal dominant,
hypertensive, hyperkalemic disorder particularly responsive to thiazide diuretics, a first-line
treatment in essential hypertension. To elucidate the novel WNK1 BP control pathway active
in distal nephron, WNK1 expression in mouse was studied. It was found that WNK1 is highly
expressed in testis> heart, lung, kidney, placenta> skeletal muscle, brain, and widely at low …