Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
TM Loftus, DE Jaworsky, GL Frehywot, CA Townsend… - Science, 2000 - science.org
TM Loftus, DE Jaworsky, GL Frehywot, CA Townsend, GV Ronnett, MD Lane, FP Kuhajda
Science, 2000•science.orgWith the escalation of obesity-related disease, there is great interest in defining the
mechanisms that control appetite and body weight. We have identified a link between
anabolic energy metabolism and appetite control. Both systemic and intracerebroventricular
treatment of mice with fatty acid synthase (FAS) inhibitors (cerulenin and a synthetic
compound C75) led to inhibition of feeding and dramatic weight loss. C75 inhibited
expression of the prophagic signal neuropeptide Y in the hypothalamus and acted in a leptin …
mechanisms that control appetite and body weight. We have identified a link between
anabolic energy metabolism and appetite control. Both systemic and intracerebroventricular
treatment of mice with fatty acid synthase (FAS) inhibitors (cerulenin and a synthetic
compound C75) led to inhibition of feeding and dramatic weight loss. C75 inhibited
expression of the prophagic signal neuropeptide Y in the hypothalamus and acted in a leptin …
With the escalation of obesity-related disease, there is great interest in defining the mechanisms that control appetite and body weight. We have identified a link between anabolic energy metabolism and appetite control. Both systemic and intracerebroventricular treatment of mice with fatty acid synthase (FAS) inhibitors (cerulenin and a synthetic compound C75) led to inhibition of feeding and dramatic weight loss. C75 inhibited expression of the prophagic signal neuropeptide Y in the hypothalamus and acted in a leptin-independent manner that appears to be mediated by malonyl–coenzyme A. Thus, FAS may represent an important link in feeding regulation and may be a potential therapeutic target.
AAAS