Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion
NN Tandon, U Kralisz, GA Jamieson - Journal of Biological Chemistry, 1989 - ASBMB
The role of glycoprotein IV (GPIV) in platelet activation processes has been examined by
several different approaches:(i) Fab fragments of a monospecific polyclonal antibody to
purified platelet GPIV (∼ 20 µg/ml) completely inhibited platelet shape change, aggregation,
and secretion induced by collagen. Aggregation and secretion by ADP (but not shape
change) and by epinephrine were also inhibited, but there was no effect on platelet
activation induced by thrombin, arachidonate, or ionophore A23187.(ii) Purified GPIV was …
several different approaches:(i) Fab fragments of a monospecific polyclonal antibody to
purified platelet GPIV (∼ 20 µg/ml) completely inhibited platelet shape change, aggregation,
and secretion induced by collagen. Aggregation and secretion by ADP (but not shape
change) and by epinephrine were also inhibited, but there was no effect on platelet
activation induced by thrombin, arachidonate, or ionophore A23187.(ii) Purified GPIV was …