Epitope-based vaccines: an update on epitope identification, vaccine design and delivery
A Sette, J Fikes - Current opinion in immunology, 2003 - Elsevier
A Sette, J Fikes
Current opinion in immunology, 2003•ElsevierThe basic premise of the epitope-based approach to vaccine development is that, in certain
cases, the responses induced by the natural immunogen are not optimal, and can be
improved upon by isolation or optimization of specific components of the response. For
example, immunodominance is a key factor limiting the type and breadth of adaptive
immunity. Recent advances in understanding the mechanisms of immunodominance thus
represent an opportunity to further develop the epitope-based approach.
cases, the responses induced by the natural immunogen are not optimal, and can be
improved upon by isolation or optimization of specific components of the response. For
example, immunodominance is a key factor limiting the type and breadth of adaptive
immunity. Recent advances in understanding the mechanisms of immunodominance thus
represent an opportunity to further develop the epitope-based approach.
The basic premise of the epitope-based approach to vaccine development is that, in certain cases, the responses induced by the natural immunogen are not optimal, and can be improved upon by isolation or optimization of specific components of the response. For example, immunodominance is a key factor limiting the type and breadth of adaptive immunity. Recent advances in understanding the mechanisms of immunodominance thus represent an opportunity to further develop the epitope-based approach.
Elsevier