Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta

MK Georgieff, JK Wobken, J Welle, JR Burdo… - Placenta, 2000 - Elsevier
The mechanism by which iron is transported from mother to fetus is incompletely
understood. Whereas transferrin receptor (TfR) is responsible for iron uptake from maternal
serum by the syncytiotrophoblast, the proteins responsible for intracytoplasmic transport and
for delivery to the fetal serum remain unknown. The aim of this study was to determine
whether the recently characterized endosomal membrane iron transporter, divalent metal
ion transporter-1 (DMT-1), is expressed in human syncytiotrophoblast, and whether its …