[HTML][HTML] Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

R Kayed, Y Sokolov, B Edmonds, TM McIntire… - Journal of Biological …, 2004 - ASBMB
Amyloid fibrillization is multistep process involving soluble oligomeric intermediates,
including spherical oligomers and protofibrils. Amyloid oligomers have a common, generic
structure, and they are intrinsically toxic to cells, even when formed from non-disease related
proteins, which implies they also share a common mechanism of pathogenesis and toxicity.
Here we report that soluble oligomers from several types of amyloids specifically increase
lipid bilayer conductance regardless of the sequence, while fibrils and soluble low molecular …