[HTML][HTML] Cyclooxygenase (COX)-2 and COX-1 potentiate β-amyloid peptide generation through mechanisms that involve γ-secretase activity
W Qin, L Ho, PN Pompl, Y Peng, Z Zhao, Z Xiang… - Journal of Biological …, 2003 - ASBMB
In previous studies we found that overexpression of the inducible form of cyclooxygenase,
COX-2, in the brain exacerbated β-amyloid (Aβ) neuropathology in a transgenic mouse
model of Alzheimer's disease. To explore the mechanism through which COX may influence
Aβ amyloidosis, we used an adenoviral gene transfer system to study the effects of human
(h) COX-1 and hCOX-2 isoform expression on Aβ peptide generation. We found that
expression of hCOXs in human amyloid precursor protein (APP)-overexpressing (Chinese …
COX-2, in the brain exacerbated β-amyloid (Aβ) neuropathology in a transgenic mouse
model of Alzheimer's disease. To explore the mechanism through which COX may influence
Aβ amyloidosis, we used an adenoviral gene transfer system to study the effects of human
(h) COX-1 and hCOX-2 isoform expression on Aβ peptide generation. We found that
expression of hCOXs in human amyloid precursor protein (APP)-overexpressing (Chinese …