[HTML][HTML] Neurohormonal signaling pathways and the regulation of Alzheimer β-amyloid precursor metabolism
S Gandy - Trends in Endocrinology & Metabolism, 1999 - cell.com
Trends in Endocrinology & Metabolism, 1999•cell.com
Postmenopausal women on estrogen replacement appear to have their relative risk of
developing Alzheimer's disease diminished by about one half. Because brain amyloid
accumulation plays a key role in initiating Alzheimer's pathology, it is attractive to postulate
that estrogen might modulate Alzheimer's risk by inhibiting amyloid accumulation. Data and
cell biological models supporting such a scenario are reviewed here.
developing Alzheimer's disease diminished by about one half. Because brain amyloid
accumulation plays a key role in initiating Alzheimer's pathology, it is attractive to postulate
that estrogen might modulate Alzheimer's risk by inhibiting amyloid accumulation. Data and
cell biological models supporting such a scenario are reviewed here.
Abstract
Postmenopausal women on estrogen replacement appear to have their relative risk of developing Alzheimer's disease diminished by about one half. Because brain amyloid accumulation plays a key role in initiating Alzheimer's pathology, it is attractive to postulate that estrogen might modulate Alzheimer's risk by inhibiting amyloid accumulation. Data and cell biological models supporting such a scenario are reviewed here.
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