[HTML][HTML] SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
L Rui, M Yuan, D Frantz, S Shoelson… - Journal of Biological …, 2002 - ASBMB
Inflammation associates with peripheral insulin resistance, which dysregulates nutrient
homeostasis and leads to diabetes. Inflammation induces the expression of SOCS proteins.
We show that SOCS1 or SOCS3 targeted IRS1 and IRS2, two critical signaling molecules for
insulin action, for ubiquitin-mediated degradation. SOCS1 or SOCS3 bound both
recombinant and endogenous IRS1 and IRS2 and promoted their ubiquitination and
subsequent degradation in multiple cell types. Mutations in the conserved SOCS box of …
homeostasis and leads to diabetes. Inflammation induces the expression of SOCS proteins.
We show that SOCS1 or SOCS3 targeted IRS1 and IRS2, two critical signaling molecules for
insulin action, for ubiquitin-mediated degradation. SOCS1 or SOCS3 bound both
recombinant and endogenous IRS1 and IRS2 and promoted their ubiquitination and
subsequent degradation in multiple cell types. Mutations in the conserved SOCS box of …