Noninvasive detection of bladder cancer in an orthotopic murine model with green fluorescence protein cytology
M Tanaka, JR Gee, J De La Cerda, CJ Rosser… - The Journal of …, 2003 - Elsevier
PURPOSE: Orthotopic models of bladder cancer mimic the normal microenvironment and
provide an opportunity to study new therapies for superficial bladder cancer. The use of
green fluorescent protein (GFP) transduced cells provides a sensitive way of monitoring this
disease. We investigated whether examining voided urine for GFP expressing cells would
indicate the presence of GFP producing tumors in an orthotopic bladder tumor model in
nude mice. MATERIALS AND METHODS: The human bladder cancer cell lines KU-7, UM …
provide an opportunity to study new therapies for superficial bladder cancer. The use of
green fluorescent protein (GFP) transduced cells provides a sensitive way of monitoring this
disease. We investigated whether examining voided urine for GFP expressing cells would
indicate the presence of GFP producing tumors in an orthotopic bladder tumor model in
nude mice. MATERIALS AND METHODS: The human bladder cancer cell lines KU-7, UM …