[HTML][HTML] Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in irs2–/–mice

R Suzuki, K Tobe, M Aoyama, A Inoue… - Journal of Biological …, 2004 - ASBMB
We previously reported that insulin receptor substrate-2 (IRS-2)-deficient mice develop
diabetes as a result of insulin resistance in the liver and failure of β-cell hyperplasia. In this
study we introduced the IRS-2 gene specifically into the liver of Irs2–/–mice with adenovirus
vectors. Glucose tolerance tests revealed that the IRS-2 restoration in the liver ameliorated
the hyperglycemia, but the improvement in hyperinsulinemia was only partial. Endogenous
glucose production (EGP) and the rate of glucose disappearance (Rd) were measured …