Age-associated thymic atrophy is linked to a decline in IL-7 production
D Andrew, R Aspinall - Experimental gerontology, 2002 - Elsevier
Age-associated thymic atrophy results in a decline in T lymphocyte output and has been
identified as one of the key events that precede inefficient functioning of the immune system
in later life. Thymic atrophy is thought to result from a failure of the thymic microenvironment
to support thymopoiesis in old age and recent evidence suggests that a decline in
interleukin-7 (IL-7) expression may limit thymocyte development by restricting combinations
of survival, proliferation and rearrangement of the TCRβ chain. Using RT-PCR and the …
identified as one of the key events that precede inefficient functioning of the immune system
in later life. Thymic atrophy is thought to result from a failure of the thymic microenvironment
to support thymopoiesis in old age and recent evidence suggests that a decline in
interleukin-7 (IL-7) expression may limit thymocyte development by restricting combinations
of survival, proliferation and rearrangement of the TCRβ chain. Using RT-PCR and the …