Administration of IgG fraction of epidermolysis bullosa acquisita (EBA) serum into mice
T Shigemoto, K Nashiro, T Tsuchida… - The Journal of …, 1988 - Wiley Online Library
T Shigemoto, K Nashiro, T Tsuchida, Y Seki, K Tamaki
The Journal of Dermatology, 1988•Wiley Online LibraryIn order to study the pathogenic role of autoantibodies in the serum of EBA patients, we tried
to induce EBA lesions in mice by administration of the IgG fraction of EBA serum via the
intraperitoneal (ip) or subcutaneous (sc) routes into neonatal or adult mice. We also tried to
induce EBA lesions in fetuses by intravenous (iv) injection of EBA serum into pregnant mice.
This study demonstrates that IgG fraction of EBA serum injected into neonatal or adult mice,
but not into fetal mice, deposits at the epidermo‐dermal junction in a linear fashion but fails …
to induce EBA lesions in mice by administration of the IgG fraction of EBA serum via the
intraperitoneal (ip) or subcutaneous (sc) routes into neonatal or adult mice. We also tried to
induce EBA lesions in fetuses by intravenous (iv) injection of EBA serum into pregnant mice.
This study demonstrates that IgG fraction of EBA serum injected into neonatal or adult mice,
but not into fetal mice, deposits at the epidermo‐dermal junction in a linear fashion but fails …
Abstract
In order to study the pathogenic role of autoantibodies in the serum of EBA patients, we tried to induce EBA lesions in mice by administration of the IgG fraction of EBA serum via the intraperitoneal (i.p.) or subcutaneous (s.c.) routes into neonatal or adult mice. We also tried to induce EBA lesions in fetuses by intravenous (i.v.) injection of EBA serum into pregnant mice.
This study demonstrates that IgG fraction of EBA serum injected into neonatal or adult mice, but not into fetal mice, deposits at the epidermo‐dermal junction in a linear fashion but fails to induce bullae. The role of EBA serum in the pathogenesis of EBA lesions is discussed.
Wiley Online Library