BRAF mutation: a frequent event in benign, atypical, and malignant melanocytic lesions of the skin
P Uribe, II Wistuba, S González - The American journal of …, 2003 - journals.lww.com
BRAF mutations have recently been detected with a high frequency (66%) in cutaneous
melanoma. All those mutations are activating, with a single substitution (T1796A) at codon
599 (V599E) accounting for over 90%. To investigate the stage in which those mutations
occur in the currently proposed sequential malignant transformation of melanocytes, 22
benign melanocytic nevi, 23 melanocytic atypical nevi, and 25 primary cutaneous melanoma
from 63 different patients were examined for BRAF mutations using DNA extracted from …
melanoma. All those mutations are activating, with a single substitution (T1796A) at codon
599 (V599E) accounting for over 90%. To investigate the stage in which those mutations
occur in the currently proposed sequential malignant transformation of melanocytes, 22
benign melanocytic nevi, 23 melanocytic atypical nevi, and 25 primary cutaneous melanoma
from 63 different patients were examined for BRAF mutations using DNA extracted from …