A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma
WH Clark Jr, DE Elder, D Guerry IV, MN Epstein… - Human pathology, 1984 - Elsevier
Six evident lesional steps of tumor progression form the neoplastic system that affects the
human epidermal melanocyte: 1) the common acquired melanocytic nevus; 2) a melanocytic
nevus with lentiginous melanocytic hyperplasia, ie, aberrant differentiation; 3) a melanocytic
nevus with aberrant differentiation and melanocytic nuclear atypia, ie, melanocytic
dysplasia; 4) the radial growth phase of primary melanoma; 5) the vertical growth phase of
primary melanoma; and 6) metastatic melanoma. The common acquired melanocytic nevus …
human epidermal melanocyte: 1) the common acquired melanocytic nevus; 2) a melanocytic
nevus with lentiginous melanocytic hyperplasia, ie, aberrant differentiation; 3) a melanocytic
nevus with aberrant differentiation and melanocytic nuclear atypia, ie, melanocytic
dysplasia; 4) the radial growth phase of primary melanoma; 5) the vertical growth phase of
primary melanoma; and 6) metastatic melanoma. The common acquired melanocytic nevus …